Hydrochloric Acid → HCID 131719045, compound

Participants

Reaction Conditions

Reaction Steps

1.3 ml of ethylmorpholine and 2.2 g of DCC are added to a stirred solution of 3.88 g of Fmoc-D-Pal-OH (10 mmol), 4.73 g of HCl.H-Ser(tBu)-Tyr(tBu)-OtBu and 1.35 g of HOBt in 40 ml of dimethylformamide at 0° C. The mixture is stirred at 0° C. for 1 hour and left to stand at room temperature overnight. The precipitate is filtered off with suction and the residue is dissolved in ethyl acetate. The solution is extracted successively with water, saturated NaHCO3 solution, KHSO4 buffer and water, dried over sodium sulfate and concentrated.

Provenance & Evidence