関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | HCID 178474472 | HCID 178474472 | — |
| 触媒 | Tetraethylammonium Chloride | HCID 5946 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(6-chloro-7H-purin-2-yl)acetamide | HCID 6098997 | 81.1% |
反応手順
60.0 g (0.36 mol) of tetraethylammonium chloride and 20.3 g (0.2 mol) of triethylamine are added to a suspension of 42.6 g (0.18 mol) of 2,9-diacetylguanine in 450 ml of acetonitrile. 165.3 g (1.08 mol) of phosphorus oxychloride are then added at a temperature of the reaction mixture of 0° C. to 5° C. The mixture is stirred at 25° C. for 20 hours and then worked up as in Example 1. 30.9 g of 2-acetamido-6-chloropurine are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05434263 |
|---|
| 出典データセット | uspto-grants-1995_07 |
|---|
| ORD ID | ord-7bfd122aa2cd4075b61737d5beddf67a |
|---|
| 出典メモ | uspto-grants-1995_07 |
|---|
