2-Fluoropyridine → HCID 10825211, compound

Participants

Reaction Steps

Metalation of 2-fluoropyridine was performed as described in Estel et al, J Org Chem (1988) 53:2740-2744. The lithium anion was quenched with 1 eq. of trimethyl tin chloride in THF (1 M) at -78° C. and stirred for 30', quenched with 1 M sodium bicarbonate and extracted with ethyl acetate. Upon Na2SO4 drying and evaporation under reduced pressure the resulting oil was used without further purification.

Provenance & Evidence