Benzoyl Peroxide → HCID 19922604, compound

Participants

Reaction Steps

Fifty (50) g of methyl-2-(3-chloro-4-methylphenyl)propionate, 42 g of N-bromosuccinimide and 600 ml of carbon tetrachloride were mixed together to form a mixed liquid which was then incorporated with a catalytic amount of benzoyl peroxide and refluxed under agitation for one hour. After the end of the reaction, the reaction mixture was filtered to remove insolubles and obtain a filtrate which was then freed of the solvent at a reduced pressure. The residue obtained was introduced into a silica gel-packed column to be adsorbed thereon and then eluted with isopropyl ether-hexane (1:10) to obtain an eluate. The thus obtained eluate was freed of the solvent thereby to obtain 31 g of methyl-2-(4-bromomethyl-3-chlorophenyl)propionate.

Provenance & Evidence