Hydrochloric Acid → HCID 15289642, compound

Participants

Reaction Steps

5 g of methyl-2-[3-chloro-4-(2-oxocyclopentane-1-yl methyl)phenyl]propionate were incorporated with 80 ml of an aqueous methanol containing 2.9 g of potassium hydroxide and then refluxed under heat for two hours. After the completion of the reaction, the reaction mixture obtained was treated to concentrate the solvent at a reduced pressure, incorporated with 50 ml of water, washed with 50 ml of ethyl acetate, after which the aqueous layer obtained was adjusted to a pH of 2 with conc. hydrochloric acid, thereafter extracted with 60 ml of ether, washed with water, dried and then freed of the solvent to obtain a residue. The thus obtained residue was distilled at a reduced pressure thereby to obtain 4.2 g (yield 88%) of oily 2-[3-chloro-4-(2-oxocyclopentane-1-yl methyl)phenyl]propionic acid.

Provenance & Evidence