Sodium Hydroxide → HCID 22854872, compound

Participants

Reaction Steps

3 g of methyl-2-[3-chloro-4-(cis-2-hydroxycyclohexane-1-yl methyl)phenyl]propionate was incorporated with 80 ml of an aqueous methanol containing 1.2 g of sodium hydroxide and then refluxed under heat for two hours. After the end of the reaction, the reaction mixture was treated to remove the solvent therefrom at a reduced pressure, incorporated with 50 ml of water and washed with 50 ml of ethyl acetate, after which the aqueous layer was adjusted to a pH of 2 with conc. hydrochloric acid, extracted with 50 ml of ethyl acetate, washed with water, dried and then freed of the solvent thereby to obtain 2.3 g (yield 80%) of oily 2-[3-chloro-4-(cis-2-hydroxycyclohexane-1-yl methyl)phenyl]propionic acid having the following instrumental analyses.

Provenance & Evidence