2,3-dihydro-7-hydroxy-8-propyl-4H-1-benzopyran-4-one → 3-(2-Carboxyethyl)-4-[5-[(3,4-dihydro-4-oxo-8-propyl-2H-1-benzopyran-7-yl)oxy]pentyloxy]-gamma-oxobenzenebutanoic Acid

Participants

Reaction Steps

Starting with 0.156 g (0.76 mmol) of 2,3-dihydro-7-hydroxy-8-propyl-4H-1-benzopyran-4-one, and 0.357 g (0.76 mmol) of 4-[(5-bromopentyl)oxy]-3-(3-ethoxy-3-oxopropyl)-γ-oxobenzenebutanoic acid ethyl ester, the title compound (0.237 g; 63.8% overall yield) was obtained as a white solid, mp 181.5°-184° C. (recrystallized from ethanol-ethyl acetate), using the procedure of example 22.

Provenance & Evidence