HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 3-(3-Ethoxy-3-oxopropyl)-4-methoxy-gamma-oxobenzenebutanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Ethyl 3-(2-methoxyphenyl)propanoate | HCID 578401 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(3-Ethoxy-3-oxopropyl)-4-methoxy-gamma-oxobenzenebutanoic Acid | HCID 19922091 | 77.7% |
Reaction Steps
Starting with a mixture of 3.12 g (15.0 mmol) of 2-methoxybenzenepropanoic acid ethyl ester, 1.53 g (15.3 mmol) of succinic anhydride, 4.46 g (33.5 mmol) of aluminum chloride and 20 mL of methylene chloride, the title compound (3.59 g, 77.7%) was obtained as a white solid, mp 128°-129° C. (recrystallized from ethanol), using the procedure of example 139.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05434186 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-72227cab3eef4169ac5a314f0f6491b1 |
| Source note | uspto-grants-1995_07 |