6-Hydroxy-5-propyl-3,4-dihydro-2H-naphthalen-1-one → 2-[(5-Carboxypentyl)oxy]-6-[6-[(5,6,7,8-tetrahydro-5-oxo-1-propyl-2-naphthalenyl)oxy]hexyl]benzenepropanoic Acid

Participants

Reaction Steps

Using the procedure of example 184, 6-hydroxy-5-propyl-1,2,3,4-tetrahydronaphthalen-1-one from example 9 was converted into the title compound by alkylation with 2-[(6-methoxy-6-oxohexyl)oxy]-6-[6-[(methylsulfonyl)oxy]hexyl]benzenepropanoic acid methyl ester from example 156, followed by saponification, in 68% overall yield. The diacid product was a colorless solid, mp 100°-101° C., recrystallized from hexane-ethyl acetate.

Provenance & Evidence