反应详情

The title compound was prepared following the method of Example 1 from 4.0 g (21.74 mmole) of 2-fluorofluorene, 8.92 g of 4-picolylchloride hydrochloride, 120 ml of toluene, 200 mg of benzyltriethylammonium chloride, and 20 ml of 50% sodium hydroxide by reaction at 22° for 17 hrs. The product was chromatographed (silica, CH2Cl2 /MeOH, 10:1) to yield 2.9 g which was recrystallized (ethanol-acetone) and converted to the dihydrochloride, m.p.>300°.

1. customby reaction at 22° for 17 hrs
2. customThe product was chromatographed (silica, CH2Cl2 /MeOH, 10:1)
3. customto yield 2.9 g which
4. customwas recrystallized (ethanol-acetone)