HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Azafluorene → HCID 10545749, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Azafluorene | HCID 9205 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Chloromethyl)pyridine | HCID 74571 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 10545749 | HCID 10545749 | 45.4% |
Reaction Steps
Following the procedure described in Example 608, Part D, alkylation of 2.1 g (12.6 mmole) of 4-azafluorene, in the presence of 1.51 g (31.45 mmole) of 50% sodium hydride with 5.0 g (30.4 mmole) of 4-picolyl-chloride yielded 2.8 g. Flash chromatography with ethyl acetate yielded 2.0 g of material containing a small amount of color. Recrystallization from butyl chloride yielded 1.5 g of pure compound, m.p. 163°-164°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05434264 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-40fdc87cfd574b8cb7a572ac309e2214 |
| Source note | uspto-grants-1995_07 |