HCID 16061417, compound → HCID 18913799, compound

HRID 1648170Notes

Reaction equation

HRID 1648170 reaction equation
CCCC1C=CC(OC2C=CC=CC=2)=C(O)C=1.[CH3:18][O:19][C:20]1[CH:50]=[CH:49][C:48]([N+:51]([O-])=O)=[CH:47][C:21]=1[CH2:22][N:23]1[CH2:34][CH2:33][N:32]([CH2:35][C:36]([OH:38])=[O:37])[CH2:31][CH2:30][N:29]([CH2:39][C:40]([OH:42])=[O:41])[CH2:28][CH2:27][N:26]([CH2:43][C:44]([OH:46])=[O:45])[CH2:25][CH2:24]1>>[CH3:18][O:19][C:20]1[CH:50]=[CH:49][C:48]([NH2:51])=[CH:47][C:21]=1[CH2:22][N:23]1[CH2:24][CH2:25][N:26]([CH2:43][C:44]([OH:46])=[O:45])[CH2:27][CH2:28][N:29]([CH2:39][C:40]([OH:42])=[O:41])[CH2:30][CH2:31][N:32]([CH2:35][C:36]([OH:38])=[O:37])[CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 16061417HCID 16061417, compoundHCID 18913790HCID 18913790, compound

Product 1

HCID 18913799HCID 18913799, compoundYield 95%

Procedure

To a nitrogen purged aqueous (50 ml) solution containing 50 mg of Pt02 was added 50 mg of 1-(2-methoxy-5-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acid (prepared by the procedure of Example 23). After hydrogenating in a Parr bomb for one hour, the solution was filtered and the aqueous filtrate freeze-dried to give the aniline derivative as a tan solid (95 percent yield), MP>240° C. dec, and further characterized by:

Workup

  1. customprepared by the procedure of Example 23)
  2. filtrationthe solution was filtered
  3. customthe aqueous filtrate freeze-dried

Sources & evidence

ORD record
ord-4e3b10e3a8b048328470ef1691192166
Source dataset
uspto-grants-1995_07
Patent number
US05435990

Reaction notes

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