5-(2-fluorophenyl)-2,2-dimethyl-6-methyl-4H-1,3-dioxin-4-one → 5-(2-fluorophenyl)-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one

Participants

Reaction Steps

Xylene (2 ml ) was added to a mixture of 5-(2-fluorophenyl)-2,2 ,6-trimethyl-2H,4H-1,3-dioxin-4-one (compound of Example 1 ) (0.71 g) and N-methylene-1-methyl1-(3-chlorophenyl)ethylamine (compound of Example 3) (0.6 g), and the resulting mixture was heated at reflux for 20 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.9 g).

Provenance & Evidence