2,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-one → 3-(1,1-dimethyl-2-phenylethyl)6-methyl-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648197Notes

Reaction equation

HRID 1648197 reaction equation
[C:1]1([C:7]2[C:8](=[O:16])O[C:10](C)(C)[O:11][C:12]=2[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=[N:18][C:19]([CH3:28])([CH3:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:28][C:19]([N:18]1[C:8](=[O:16])[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[C:12]([CH3:13])[O:11][CH2:10]1)([CH3:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 131570242,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-oneHCID 15568651N-methylene-1,1-dimethyl-2-phenylethylamine

Product 1

HCID 199189533-(1,1-dimethyl-2-phenylethyl)6-methyl-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-oneYield 77.3%

Procedure

5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g) and N-methylene-1,1-dimethyl-2-phenylethylamine (0.63 g) were reacted at 140° for 30 minutes. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.74 g).

Workup

  1. customThe reaction mixture was purified by silica gel chromatography

Sources & evidence

ORD record
ord-6c544c79a5cd4a3e8b40b8803ab0139b
Source dataset
uspto-grants-1995_07
Patent number
US05436224

Reaction notes

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