HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxyquinoline → 1,2-Dihydro-1,4-dimethyl-8-phenyl-2-quinolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxyquinoline | HCID 6038 | — |
| Reactant | Diketene | HCID 12661 | — |
| Reactant | N-Methylbiphenyl-2-amine | HCID 12246986 | — |
| Solvent | Acetic acid sulfuric acid | HCID 23350293 | — |
| Product | 1,2-Dihydro-1,4-dimethyl-8-phenyl-2-quinolone | HCID 19918917 | — |
Reaction Steps
The starting material is 2-phcnylaniline, which is methylated with potassium carbonate and methyl iodide to obtain N-methyl-2-phenylaniline. The N-methyl-2-phenylaniline is treated with diketene and acid and is cyclized in acetic acid/sulfuric acid as in Example 3 to generate the desired quinolone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05436134 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-828071d3eb02426783cb8203d20b079c |
| Source note | uspto-grants-1995_07 |