Isoniazid → HCID 12795759, compound

HRID 1648242Notes

Reaction equation

[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.ClC1C=CC(C(NN)=O)=CC=1.[CH3:22][N:23]=[C:24]=[O:25].C(N=C=O)C>>[N:5]1[CH:6]=[CH:7][C:2]([C:1]([NH:9][NH:10][C:24]([NH:23][CH3:22])=[O:25])=[O:8])=[CH:3][CH:4]=1

Participants

Reactant 4

HCID 3767Isoniazid

HCID 8022Ethyl isocyanate

HCID 108164-Chlorobenzohydrazide

HCID 12228Methyl Isocyanate

Product 1

HCID 12795759HCID 12795759, compound

Procedure

When, in the procedure of Example 1, isonicotinic acid hydrazide is substituted for 4-chlorobenzoic acid hydrazide and methyl isocyanate is substituted for ethyl isocyanate, the title compound is obtained.

Sources & evidence

ORD record: ord-44697c168ffa470db95481fed8acc65f
Source dataset: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05436252

Reaction notes

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