Sulfuric Acid → HCID 22097606, compound

HRID 1648270Notes

Reaction equation

HRID 1648270 reaction equation
[NH2:1][C:2]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[CH:16][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][CH3:15])[CH:7]=1)=O.[CH2:24]([O:26][C:27](=[O:39])[CH2:28][C:29](=O)[CH2:30][CH2:31][CH2:32][N:33]1[CH:37]=[CH:36][N:35]=[CH:34]1)[CH3:25].S(=O)(=O)(O)O>C(O)(=O)C>[CH2:24]([O:26][C:27]([C:28]1[C:29]([CH2:30][CH2:31][CH2:32][N:33]2[CH:37]=[CH:36][N:35]=[CH:34]2)=[N:1][C:2]2[C:3]([C:4]=1[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][CH3:15])[CH:7]=1)=[CH:16][C:17]([O:22][CH3:23])=[C:18]([O:20][CH3:21])[CH:19]=2)=[O:39])[CH3:25]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 99269672-Amino-4,5,3',4'-tetramethoxybenzophenoneHCID 22097627Ethyl β-oxo-1H-imidazole-1-hexanoate

Product 1

HCID 22097606HCID 22097606, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

To a mixture of 2-amino-4,5,3',4'-tetramethoxybenzophenone (453 mg), 6-(1-imidazolyl)-3-oxohexanoic acid ethyl ester (320 mg) and acetic acid (5 ml), concentrated sulfuric acid (0.03 ml) was added, followed by stirring at 100° C. for 2 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured over water, alkalinized with 2N sodium hydroxide and then extracted with chloroform. The chloroform layer was washed with water and dried (MgSO4), after which the solvent was distilled off. The residual oily substance was subjected to silica gel column chromatography and eluted with chloroform-methanol (50:1, v/v) to yield 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[3-(1-imidazolyl)propyl]quinoline-3-carboxylic acid ethyl ester (310.0 mg, 43%), which was then recrystallized from ethyl acetate-hexane to yield a colorless prismatic crystal having a melting point of 164° to 165° C.

Workup

  1. additionwas added
  2. concentrationAfter the reaction mixture was concentrated under reduced pressure
  3. additionthe residue was poured over water
  4. extractionextracted with chloroform
  5. washThe chloroform layer was washed with water
  6. dry with materialdried (MgSO4)
  7. distillationafter which the solvent was distilled off
  8. washeluted with chloroform-methanol (50:1

Sources & evidence

ORD record
ord-4972a3e696d04114bc4efcb780d3a4dd
Source dataset
uspto-grants-1995_07
Patent number
US05436247

Reaction notes

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