Benzoyl Peroxide → HCID 19919354, compound

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Reaction Steps

A mixture of methyl 4-methyl-2-chloro-1H-benzimidazole-1-carboxylate (17.5 g, 0.078 mol), N-bromosuccinimide (13.9 g, 0.078 mol) and benzoyl peroxide (2.0 g) in carbon tetrachloride (175 mL) was stirred at reflux for 2 hours. The solution was cooled, filtered to remove succinimide by-products, evaporated and crystallized from ethyl acetate:hexane to give 17.1 g of methyl-4-(bromomethyl)-2-chloro-1H-benzimidazole-1-carboxylate as a pale yellow solid.

Provenance & Evidence