HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nipecotic Acid → 1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nipecotic Acid | HCID 4498 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Product | 1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid | HCID 234339 | — |
Reaction Steps
By substantially following the procedures of Example 15, A, 25.0 g (194 mmol) of nipecotic acid was protected with benzylchloroformate under basic conditions to afford 18.0 g (68 mmol; 35%) of analytically pure N-Cbz-nipecotic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05436229 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-83c837061c0c4b64b514c4db22669d78 |
| Source note | uspto-grants-1995_07 |