HCID 131719057, compound → HCID 178456203, compound

HRID 1648381Notes

Reaction equation

HRID 1648381 reaction equation
C(OC(N[C@:7]([CH2:35]CC)([C:15]([N:17]1[CH2:34][CH2:33][CH2:32][C@H:18]1[C:19]([NH:21][C@H:22]([CH:30]=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28])=[O:20])=O)CC1C=CC=CC=1)=O)C.[ClH:38].[CH2:39]([O:41][C:42]([NH:44][C@:45](CCC)([C:53](N1CCC[C@H]1C(OCC1C=CC=CC=1)=O)=[O:54])[CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)=[O:43])[CH3:40]>>[ClH:38].[CH2:39]([O:41][C:42]([NH:44][C@H:45]([C:53]([C@@:18]1([C:19]([NH:21][C@H:22]([CH:30]=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28])=[O:20])[CH2:32][CH2:33][CH2:34][N:17]1[CH2:15][CH2:7][CH3:35])=[O:54])[CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)=[O:43])[CH3:40]

Participants

3

Reactant 2

HCID 131719057HCID 131719057, compoundHCID 178442108HCID 178442108, compound

Product 1

HCID 178456203HCID 178456203, compound

Procedure

By methods substantially equivalent to those described in Example 37, 0.34 g of EtOCO-Phe(αn-Pr)-Pro-Arg-H.HCl was prepared from EtOCO-Phe(αn-Pr)-Pro-OBzl (TLC Rf =0.67, 50% ethyl acetate:hexanes). EtOCO-Phe(αn-Pr)-Pro-Arg-H.HCl was purified by RPHPLC (98/2 (A/B), 60 min; to 80/20 (A/B), 300 min).

Workup

  1. customEtOCO-Phe(αn-Pr)-Pro-Arg-H.HCl was purified by RPHPLC (98/2 (A/B), 60 min
  2. custom300 min

Sources & evidence

ORD record
ord-d2dff953d6bd451aa4514a91c7989346
Source dataset
uspto-grants-1995_07
Patent number
US05436229

Reaction notes

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