Trifluoroacetic acid → HCID 131719066, compound

Participants

Reaction Steps

To a solution of TFA.D-Phe-Pro-OBzl (10 g, 21.4 mmol) in dichloromethane (150 mL) was added N,N-diisopropylethylamine (3.73 mL, 21.4 mmol) followed by ethyl isocyanate (1.86 mL, 23.5 mmol). After stirring for 16 h, the solution was washed three times with 1N HCl, dried over Na2SO4, filtered and concentrated in vacuo to give 9.7 g (107%) of white foam.

Provenance & Evidence