5-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamine → [2-(6-fluoro-1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2-methyl-prop-1-yloxy)phenoxy]ethyl}amine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	5-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamine	HCID 13260	—
Reactant	2-[2-(2-Methylprop-1-yloxy)phenoxy]ethyl methanesulfonate	HCID 15289997	—
Reactant	1-(6-fluoro-1H-indol-3-yl)-2-methylpropan-2-amine	HCID 19919978	—
Product	[2-(6-fluoro-1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2-methyl-prop-1-yloxy)phenoxy]ethyl}amine hydrochloride	HCID 19919948	—

Reaction Steps

Proceeding as an Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(2-methylprop-1-yloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2- (6-fluoro-1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(6-fluoro-1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2-methyl-prop-1-yloxy)phenoxy]ethyl}amine hydrochloride, m.p. 135°-137° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05436264
Source dataset	uspto-grants-1995_07
ORD ID	ord-cc96e3404e7b43729056680b6d7c151d
Source note	uspto-grants-1995_07