1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 19919911, compound

HRID 1648405Notes

Reaction equation

HRID 1648405 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[O:16][CH2:17][CH:18]([CH3:20])[CH3:19])(=O)=O.[Cl:21][C:22]1[CH:23]=[C:24]2[C:28](=[CH:29][CH:30]=1)[NH:27][CH:26]=[C:25]2[CH2:31][C:32]([NH2:35])([CH3:34])[CH3:33].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:21].[NH:27]1[C:28]2[C:24](=[CH:23][CH:22]=[CH:30][CH:29]=2)[C:25]([CH2:31][C:32]([NH:35][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[O:16][CH2:17][CH:18]([CH3:19])[CH3:20])([CH3:33])[CH3:34])=[CH:26]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 15289633HCID 15289633, compound

Product 1

HCID 19919911HCID 19919911, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[4-fluoro-2-(2-methylprop-1-yloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[4-fluoro-2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride, m.p. 155°-156° C.

Sources & evidence

ORD record
ord-66ff7e0a13a24da1a07d7d0a401c2ee8
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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