1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 19919921, compound

HRID 1648406Notes

Reaction equation

HRID 1648406 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][CH:17]=[CH2:18])(=O)=O.[Cl:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][CH:24]=[C:23]2[CH2:29][C:30]([NH2:33])([CH3:32])[CH3:31].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:19].[NH:25]1[C:26]2[C:22](=[CH:21][CH:20]=[CH:28][CH:27]=2)[C:23]([CH2:29][C:30]([NH:33][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH:17]=[CH2:18])([CH3:31])[CH3:32])=[CH:24]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919946HCID 19919946, compound

Product 1

HCID 19919921HCID 19919921, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(2-propenyloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2-propenyloxy)phenoxy]ethyl}amine hydrochloride, m.p. 55°-156° C.

Sources & evidence

ORD record
ord-0771cc17e6fa47bca7dda200dca0f6ce
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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