1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 19919964, compound

HRID 1648407Notes

Reaction equation

HRID 1648407 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][C:17](=[O:19])[CH3:18])(=O)=O.[Cl:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][C:31]([NH2:34])([CH3:33])[CH3:32].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:20].[NH:26]1[C:27]2[C:23](=[CH:22][CH:21]=[CH:29][CH:28]=2)[C:24]([CH2:30][C:31]([NH:34][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][C:17](=[O:19])[CH3:18])([CH3:32])[CH3:33])=[CH:25]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919929HCID 19919929, compound

Product 1

HCID 19919964HCID 19919964, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(2-oxopropyloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2- oxopropyloxy)phenoxy]ethyl}amine hydrochloride.

Sources & evidence

ORD record
ord-8a5f13db7ec9433a92c00393abc75c24
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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