1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 67809513, compound

HRID 1648408Notes

Reaction equation

HRID 1648408 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=O)=O.[Cl:23][C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[NH:29][CH:28]=[C:27]2[CH2:33][C:34]([NH2:37])([CH3:36])[CH3:35].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:23].[NH:29]1[C:30]2[C:26](=[CH:25][CH:24]=[CH:32][CH:31]=2)[C:27]([CH2:33][C:34]([NH:37][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)([CH3:35])[CH3:36])=[CH:28]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919910HCID 19919910, compound

Product 1

HCID 67809513HCID 67809513, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-(2-benzyloxyphenoxy)ethyl methanesulfonate and [2- (5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2- (2-benzyloxyphenoxy)ethyl}amine hydrochloride, m.p. 148°-150° C.

Sources & evidence

ORD record
ord-9a5b186803734e4ebc59fd8ebb8119cb
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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