1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 19919918, compound

HRID 1648409Notes

Reaction equation

HRID 1648409 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=O)=O.[Cl:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[NH:30][CH:29]=[C:28]2[CH2:34][C:35]([NH2:38])([CH3:37])[CH3:36].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:24].[NH:30]1[C:31]2[C:27](=[CH:26][CH:25]=[CH:33][CH:32]=2)[C:28]([CH2:34][C:35]([NH:38][CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:36])[CH3:37])=[CH:29]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919915HCID 19919915, compound

Product 1

HCID 19919918HCID 19919918, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 3-(2-benzyloxyphenoxy)prop-1-yl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2- (1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{3-(2-benzyloxyphenoxy)prop-1-yl}amine hydrochloride.

Sources & evidence

ORD record
ord-e03ad655e40949b1920a5ddad38732f6
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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