1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 19919966, compound

HRID 1648410Notes

Reaction equation

HRID 1648410 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][CH:17]1[CH2:21][CH2:20][CH2:19][O:18]1)(=O)=O.[Cl:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][CH:27]=[C:26]2[CH2:32][C:33]([NH2:36])([CH3:35])[CH3:34].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:22].[NH:28]1[C:29]2[C:25](=[CH:24][CH:23]=[CH:31][CH:30]=2)[C:26]([CH2:32][C:33]([NH:36][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19][O:18]2)([CH3:34])[CH3:35])=[CH:27]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919971HCID 19919971, compound

Product 1

HCID 19919966HCID 19919966, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(tetrahydrofur-2-ylmethyloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(tetrahydrofur-2-ylmethyloxy)phenoxy]ethyl}amine hydrochloride.

Sources & evidence

ORD record
ord-928357d3c02f44cb8d1ac605af1bd9f6
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

Loading…