1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 67809060, compound

HRID 1648411Notes

Reaction equation

HRID 1648411 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15]C(C1C=CC=CC=1)C1C=CC=CC=1)(=O)=O.[Cl:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][CH:34]=[C:33]2[CH2:39][C:40]([NH2:43])([CH3:42])[CH3:41].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:29].[NH:35]1[C:36]2[C:32](=[CH:31][CH:30]=[CH:38][CH:37]=2)[C:33]([CH2:39][C:40]([NH:43][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[OH:15])([CH3:42])[CH3:41])=[CH:34]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919920HCID 19919920, compound

Product 1

HCID 67809060HCID 67809060, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(diphenylmethyloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, and then deprotecting, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl][2- (2-hydroxyphenoxy)ethyl]amine hydrochloride.

Sources & evidence

ORD record
ord-47972813901f42d9a7e28c3e50cde8b0
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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