5-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamine → [2-(6-hydroxy-1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride

Participants

Reaction Steps

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(2-methylprop-1-yloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(6-diphenylmethyloxy-1H-indol-3-yl)-1,1-dimethylethyl]amine and then removing the protective group, gave [2-(6-hydroxy-1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride.

Provenance & Evidence