Hydrochloric Acid → 1-(4-Aminophenoxy)propan-2-one hydrochloride

Participants

Reaction Steps

A stream of hydrogen was passed through a mixture comprising 19.6 g of 1-(4-nitrophenoxy)propan-2-one, 300 ml of methanol, 30 ml of concentrated aqueous hydrochloric acid and 4 g of 10% w/v palladium-on-charcoal at room temperature for 5 hours. At the end of this time, the catalyst was filtered off, and the filtrate was concentrated by evaporation under reduced pressure, to give 20 g of the title compound. This compound was used directly and without further purification in the next step.

Provenance & Evidence