Water → HCID 11027585, compound

Participants

Reaction Steps

3.43 g of triethylamine were added to a solution of 9.0 g of 5-(4-acetoxybenzyl)thiazolidine-2,4-dione [prepared as described in step (b) above] in 70 ml of methylene chloride, and a solution of 9.45 g of triphenylmethyl chloride in 30 ml of methylene chloride was added dropwise to the resulting mixture. The mixture was then stirred at room temperature for one hour, after which it was allowed to stand overnight at the same temperature. At the end of this time, the reaction mixture was mixed with water and ethyl acetate, and the organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the crystals which separated were washed with a mixture of hexane and ethyl acetate and dried, to give 7.86 g of the title compound, melting at between 152° C. and 156° C. 11(d) 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione

Provenance & Evidence