Tetrabutylammonium Fluoride → HCID 86748816, compound

Participants

Reaction Steps

A procedure similar to that described in Preparation 4, above, was followed, but using 350 mg of 5-(4-{2(R)-[2(R)-(3-chlorophenyl)-2-t-butyldimethylsilyloxyethylamino]-4-methylpentyloxy}benzyl]thiazolidine-2,4 -dione [prepared as described in Preparation 18], 1,39 g of tetrabutyl ammonium fluoride and 10 ml of tetrahydrofuran to obtain the title compound in crude form. This crude product was then purified by column chromatography through silica gel, using a 1:1 by volume mixture of ethyl acetate and hexane as the eluent, to give 180 mg of the title compound, having an Rf=0.28 (thin layer chromatography on silica gel, using a 1:1 by volume mixture of ethyl acetate and hexane as the developing solvent).

Provenance & Evidence