HCID 12750603, compound → HCID 15288194, compound

Participants

Reaction Steps

A stirred solution of 2.0 g of the product of Example 6 and 500 mg of lithium aluminum hydride in 200 ml of tetrahydrofuran is refluxed for 4 hours. The reaction mixture is carefully quenched with ice cold water and extracted with chloroform. The organic layer is washed well with water, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to a residue. The residue is purified by column chromatography on silica gel by elution with 30% ethyl acetatehexane to give 1.2 g of the desired product as a bright yellow solid, M+ =202.

Provenance & Evidence