HCID 9884032, compound → HCID 178506684, compound

Participants

Reaction Steps

In a separate flask, the oxazolidine in the form of the mixture of Example 1 (17.43 g, 52.62 mmol, 1 eq) was dissolved in 25 mL of THF under an argon atmosphere. The solution was cooled to -70° C. (internal temperature) and n-C4H9Li (n-BuLi) (21 mL, 52.5 mmol, 1 eq) was added dropwise over 10 min such that the internal temperature did not rise above -50° C. The reaction was brought back to -70° C., and stirred for 2 h.

Provenance & Evidence