Sodium Hydroxide → HCID 15933201, compound

HRID 1648501Notes

Reaction equation

HRID 1648501 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:10][CH:9]1[CH2:11][CH2:12][C:13]([O:15]C)=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C>[C:1]([O:5][C:6]([N:8]1[CH:9]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15933186HCID 15933186, compound

Product 1

HCID 15933201HCID 15933201, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1 mmol of 3 5 mL of ethanol is added 2 mL of 1N NaOH and the mixture is stirred for 2 hours at ambient temperature. The mixture is partitioned between 25 mL of water and 25 mL of ether. The aqueous layer is acidified to pH 2 and extracted with 2×25 mL of ether. The combined either extracts are washed with brine, dried with anhydrous MgSO4, filtered and concentrated to yield 4.

Workup

  1. customThe mixture is partitioned between 25 mL of water and 25 mL of ether
  2. extractionextracted with 2×25 mL of ether
  3. washextracts are washed with brine
  4. dry with materialdried with anhydrous MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto yield 4

Sources & evidence

ORD record
ord-cf795a85bb534f28aa45c2d9a18a4b15
Source dataset
uspto-grants-1995_07
Patent number
US05436352

Reaction notes

Loading…