1-Methylhydantoin → HCID 67787144, compound

Participants

Reaction Steps

This compound is prepared by a procedure similar to Example 1 except that the starting materials are the ester derivative, 2-butyl-1-(4-carbomethoxybenzyl)-5-formylimidazole, and 1-methylhydantoin. The crude mixed isomer products are purified and separated by silica gel column chromatography, eluting with 0.1:1.5:10 glacial acetic acid-methanol-chloroform. The "slow" moving material is the (E) isomer; tlc (0.1:2:10 acetic acid-methanol-chloroform system) 1 spot, Rf 0.5; mp 219°-221° C.; nmr (DMSO-d6), vinyl proton at δ 5.96 ppm; MS (CI) 383 (M39 +1).

Provenance & Evidence