HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Diethyl 1-hexyl-2,5-dioxo-4-imidazolylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Iodohexane | HCID 12527 | — |
| Reactant | Diethyl (2,5-dioxo-2,5-dihydro-1H-imidazol-4-yl)phosphonate | HCID 53733419 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Diethyl 1-hexyl-2,5-dioxo-4-imidazolylphosphonate | HCID 53646860 | — |
Reaction Steps
To a solution of diethyl 2,5-dioxo-4-imidazolylphosphonate (6.00 g, 0.025 moles) in DMF (15 mL), under N2, is added K2CO3 (17.5g, 0.127 moles) and 1-iodohexane (3.75 mL, 0.025 moles). This mixture is stirred at room temperature for 16 hours. The mixture is diluted with ether (300 mL) and washed with water and brine and then dried over MgSO4. Evaporation of solvents under high vacuum affords the required product as a viscous yellow oil. (Mass spectrometry also revealed a small amount of diethyl 1,3-dihexyl-2,5-dioxo-4-imidazolylphosphonate) MS (EI) 321
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05436260 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-f154442dadb24ac08901a1f58bdbd0df |
| Source note | uspto-grants-1995_07 |