Acetic Acid → HCID 178441607, compound

Participants

Reaction Steps

To a mixture of the E and Z-isomers of 5-[[2-butyl-3-[[2'-(N-triphenylmethyl-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]methyl]-3H-imidazol-4-yl]methylene]-1-methyl-2,4-imidazolidinedione (0.400 g, 0.552 mmol ) was added methanol (50 mL) and glacial acetic acid (0.2 mL). This white heterogeneous mixture was refluxed for 3 hour in which time a solution formed. The solution was cooled to room temperature and diluted with water (5 mL) and hexanes (50 mL). The aqueous methanol fraction was evaporated in vacuo and then triturated with ethyl acetate. The insoluble residue was collected and determined to be the E-isomer. HPLC eluant 45%(0.1%TFA in H2O) 55% MeCN, RT 1.9[95%] MS (CI) 483 (M+1)

Provenance & Evidence