4,5-Difluorophthalic Acid → 4,5-Difluorophthalic Anhydride

HRID 1648536Notes

Reaction equation

HRID 1648536 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5](=[CH:9][C:10]=1[F:11])[C:6]([OH:8])=O>C(OC(=O)C)(=O)C>[F:11][C:10]1[CH:9]=[C:5]2[C:6](=[O:8])[O:14][C:12](=[O:13])[C:4]2=[CH:3][C:2]=1[F:1]

Participants

3

Reactant 1

HCID 6433824,5-Difluorophthalic Acid

Product 1

HCID 6397454,5-Difluorophthalic AnhydrideYield 95%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

The title compound of Example 2 (28.2 g, 139.5 mmol) was suspended in 90 ml of acetic anhydride and heated to reflux for 2 hours. The reaction was evaporated to dryness to give 24.4 g of the title compound as crude product (95% yield). 1H NMR(CDCI3) : 7.73 (t). I.R.: 3025 (m), 1877 (m), 1794 (vs), 1505 (s) , 1220 (vs), 910 (s) , 780 (rs) cm-1.

Workup

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. customThe reaction was evaporated to dryness

Sources & evidence

ORD record
ord-ed28d29ddc38469099a555a56ce90860
Source dataset
uspto-grants-1995_07
Patent number
US05436368

Reaction notes

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