Nitric Acid → HCID 19031177, compound

HRID 1648555Notes

Reaction equation

HRID 1648555 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][C:8]2=[O:9])[CH2:3][CH2:2]1.S(=O)(=O)(O)O.[N+:23]([O-])([OH:25])=[O:24]>>[N+:23]([C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][CH:15]=1)[N:7]([CH:4]1[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]1)[C:8](=[O:9])[CH2:10][CH2:11]2)([O-:25])=[O:24]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 107281851-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 19031177HCID 19031177, compound

Procedure

1-(4-Piperidinyl)-3,4-dihydrocarbostyril (0.2 g) is added to conc. sulfuric acid (5 ml) and thereto is added fuming nitric acid (0.1 ml) under ice cooling. The mixture is stirred at room temperature for 30 minutes, and then the reaction mixture is poured into ice-water. The mixture is basified and extracted with dichloromethane. The solvent is concentrated to give 6-nitro-1-(4-piperidinyl)-3,4-dihydrocarbostyril (0.2 g).

Workup

  1. extractionextracted with dichloromethane
  2. concentrationThe solvent is concentrated

Sources & evidence

ORD record
ord-5e572860a2854ddc9cd4ba88401719fb
Source dataset
uspto-grants-1995_07
Patent number
US05436254

Reaction notes

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