2,5-Dimethoxytetrahydrofuran → HCID 19030902, compound

Participants

Reaction Steps

A mixture of 1-{1-[4-(4-aminobutoxy)benzoyl]-4-piperidinyl)-3,4-dihydrocarbostyril (0.50 g), acetic acid (10 ml) and 2,5-dimethoxytetrahydrofuran (0.17 ml) is refluxed with stirring under heating for 1 hour. The reaction solution is concentrated under reduced pressure and the resulting residue is purified by silica gel column chromatography (solvent: dichloromethane:methanol=100:1) to give 1-[1-{4-[4-(1-pyrrolyl)butoxy]benzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (0.30 g).

Provenance & Evidence