HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → (E)-N-ethyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3,3-Dimethyl-1-butyne | HCID 13512 | — |
| Reactant | 1,3-Dichloropropene | HCID 24883 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | (E)-N-ethyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochloride | HCID 19917114 | 74% |
Reaction Steps
By using 145 ml (1.79 mol) of 70% ethylamine aqueous solution instead of n-propylamine, 255 ml of tetahydrofuran, 27.3 ml (0.296 mol) of 1,3-dichloropropene (E/Z =9/1), 2.85 g (15 mmol) of copper (I) iodide, 1.07 g (6.0 mmol) of palladium chloride, 3.15 g (12 mmol) of triphenylphosphine and 45.0 ml (0.365 mol) of tert-butylacetyiene, the treatment was conducted in the same manner as in Example 1 to obtain 44.4 g (yield: 74%) of the above identified compound as slightly yellowish brown crystalline powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05436354 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-36981e53d3024be78f8be6177b007a23 |
| Source note | uspto-grants-1995_07 |