Butylamine → HCID 11024104, compound

Participants

Reaction Steps

To 10 ml tetrahydrofuran were added 1.44 g (5 mmol) of (E)-N-(3-chloro-2-propenyl)-N-ethyl-3-bromobenzylamine, 47.6 mg (0.25 mmol) of copper (I) iodide and 22.4 mg (0.1 mmol) of palladium acetate and 52.5 mg (0.2 mmol) of triphenylphosphine, and further, 1.0 ml (10 mmol) of n-butylamine and 0.74 ml (6 mmol) of tert-butylacetylene under ice cooling. The mixture was stirred for 20 hours at room temperature, and concentrated under reduced oressure. The residue was subjected to silica gel chromatography (n-hexane→n-hexane/ethyl acetate =20/1). The desired fractions were put together and concentrated under reduced pressure to obtain 1.37 g (yield: 82% ) of the above identified compound as an oil.

Provenance & Evidence