Sodium Carbonate → HCID 20481704, compound

Participants

Reaction Steps

Ethyl 2-bromo-9-tetrahydropyranyloxy-nonanoate (2.5 g) and 3-hydroxy-3-methylnonylamine (2.2 g) were refluxed together in dry ethanol (50 ml) containing sodium carbonate (726 mg) overnight. The ethanol was evaporated in vacuo and the residue was partitioned between ether and brine. The ether solution was washed with brine, dried and evaporated in vacuo. The resulting yellow gum was chromatographed on silica gel (100 g) using chloroform as eluant to give ethyl 2-(3'-hydroxy-3'-methyl-n-nonyl)amino-9-tetrahydropyranyloxy-nonanoate (1.27 g) as a colourless gum.

Provenance & Evidence