Water → p-Cyclododecylphenyl nicotinate

HRID 1648743Notes

Reaction equation

HRID 1648743 reaction equation
[CH:1]1([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1.O>N1C=CC=CC=1>[C:21]([O:19][C:16]1[CH:15]=[CH:14][C:13]([CH:1]2[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:18][CH:17]=1)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1

Participants

5

Reactant 3

HCID 962WaterHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 19391072p-Cyclododecylphenol

Product 1

HCID 12940113p-Cyclododecylphenyl nicotinate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Conditions

Temperature
0 °C

Procedure

8 g (30.8 mmol) of p-cyclododecylphenol and 5.9 g (33.2 mmol) of nicotinic acid chloride hydrochloride was mixed with 140 ml of dry pyridine and kept at 30° C. for 15 hours. Subsequently, 42 ml of water was added slowly drop by drop, and the mixture cooled to 0° C. The crystallized precipitate was sucked off, freed from pyridine by washing with water and dried.

Workup

  1. washby washing with water
  2. customdried

Sources & evidence

ORD record
ord-aee358e6b9d74a9084c59d955437fa0d
Source dataset
uspto-grants-1983_11
Patent number
US04412998

Reaction notes

Loading…