Water → HCID 14126411, compound

HRID 1648744Notes

Reaction equation

HRID 1648744 reaction equation
[CH:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1.O>N1C=CC=CC=1>[C:18]([O:16][C:13]1[CH:14]=[CH:15][C:10]([C:8](=[O:9])[CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:11][CH:12]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1

Participants

5

Reactant 3

HCID 962WaterHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 12505087HCID 12505087, compound

Product 1

HCID 14126411HCID 14126411, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Conditions

Temperature
40 °C

Procedure

11 g (50 mmol) of p-cyclohexylacetylphenol and 9.6 g (54 mmol) of nicotinic acid chloride hydrochloride was mixed with 160 ml of dry pyridine and stirred for 8 hours at 40° C. Subsequently, water (66 ml) was added drop by drop until the solution was turbid. The solution was placed in the ice bath, the precipitate sucked off, freed from pyridine by washing with water and dried.

Workup

  1. washby washing with water
  2. customdried

Sources & evidence

ORD record
ord-da71e766cbae41caa838c36b34373908
Source dataset
uspto-grants-1983_11
Patent number
US04412998

Reaction notes

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