Pyridine → HCID 70408025, compound

HRID 1648749Notes

Reaction equation

HRID 1648749 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1.Cl.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1.N1C=CC=CC=1>O>[C:18]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=1[C:9](=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 6799Chlorohydroxy benzophenoneHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

Product 1

HCID 70408025HCID 70408025, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

15 g (64,5 mmol) of p-chlorobenzoylphenol and 12 g (68 mmol) of nicotinic acid chloride hydrochloride was mixed with 200 ml dry pyridine and stirred for 24 hours at 40° C. After cooling 200 ml water were added and the precipitated product washed twice with 80 ml of water and recrystallized from methanol.

Workup

  1. additionwere added
  2. washthe precipitated product washed twice with 80 ml of water
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-b316c031647240c09077668a1d8757bc
Source dataset
uspto-grants-1983_11
Patent number
US04412998

Reaction notes

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