反应详情

温度

0 °C

A 11 g quantity (0.05 mole) of 2,3-dihydro-2,2-dimethylbenzofuran-7-yl N-methyl-carbamate was dissolved in 50 ml of chloroform, 5.2 g (0.05 mole) of sulfur dichloride was added to the solution with cooling, and 5 g (0.05 mole) of triethylamine was further added dropwise to the solution at -10° to -5° C. The mixture was stirred at 0° C. for one hour and further at room temperature for one hour. After cooling to -10° to -5° C., 6.2 g (0.05 mole) of iminodipropionitrile was added dropwise to the mixture, and 5 g (0.05 mole) of triethylamine was further added dropwise to the mixture. The resulting mixture was stirred at 0° C. for 2 hours and thereafter allowed to stand overnight at room temperature. With addition of 100 ml of chloroform, the reaction mixture was washed with 100 ml of water three times. The chloroform layer was dried and then concentrated in a vacuum to give an oily product, which was almost entirely composed of the desired product although containing small amounts of impurities. Yield: 12.2 g (65.2%).

1. temperaturewith cooling
2. temperatureAfter cooling to -10° to -5° C.
3. additionwas further added dropwise to the mixture
4. stirringThe resulting mixture was stirred at 0° C. for 2 hours
5. waitto stand overnight at room temperature
6. washthe reaction mixture was washed with 100 ml of water three times
7. dry with materialThe chloroform layer was dried
8. concentrationconcentrated in a vacuum
9. customto give an oily product, which