Methyl Isocyanate → HCID 12838119, compound

HRID 1648786Notes

Reaction equation

HRID 1648786 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[CH:27]=[CH:26][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[C:8]([O:28][CH3:29])[CH:7]=1>C1C=CC=CC=1>[CH3:1][NH:2][C:3](=[O:4])[NH:5][C:6]1[CH:27]=[CH:26][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:18][CH2:19]2)=[C:8]([O:28][CH3:29])[CH:7]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 128381041-[3-(4-Amino-2-methoxyphenoxy)-n-propyl]-4-phenylpiperazine

Product 1

HCID 12838119HCID 12838119, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

260 mg of methyl isocyanate are added to a solution of 1.0 g of 1-[3-(4-amino-2-methoxyphenoxy)-n-propyl]-4-phenylpiperazine in 60 ml of anhydrous benzene, and the mixture is stirred at room temperature for 95 hours. The crystalline precipitates are collected by filtration, and then recrystallized from isopropyl alcohol. 1.11 g of 1-{3-[4-(3-methylureido)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine are thereby obtained as colorless needles. Yield: 93%

Workup

  1. customThe crystalline precipitates
  2. filtrationare collected by filtration
  3. customrecrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-2b1f56b077254c8bb26e72204710e06c
Source dataset
uspto-grants-1983_11
Patent number
US04413006

Reaction notes

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