反应详情

260 mg of methyl isocyanate are added to a solution of 1.0 g of 1-[3-(4-amino-2-methoxyphenoxy)-n-propyl]-4-phenylpiperazine in 60 ml of anhydrous benzene, and the mixture is stirred at room temperature for 95 hours. The crystalline precipitates are collected by filtration, and then recrystallized from isopropyl alcohol. 1.11 g of 1-{3-[4-(3-methylureido)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine are thereby obtained as colorless needles. Yield: 93%

1. customThe crystalline precipitates
2. filtrationare collected by filtration
3. customrecrystallized from isopropyl alcohol